Spring Clinical | CoolSculpting
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CRYOLIPOLYSIS or CoolSculpting

Cryolipolysis is the non-invasive cooling of adipose tissue to induce lipolysis – the breaking down of fat cells – to reduce body fat without damage to other tissues. You exercise. You eat right. But some stubborn fat bulges are immune to diet and exercise. You don’t feel as confident in your own skin as you should or could. Cryolipolysis is a revolutionary non-surgical contouring treatment that freezes stubborn fat, which then is naturally eliminated from your body. The physicians and their team conducted research that demonstrated that under carefully controlled conditions, subcutaneous fat cells are naturally more vulnerable to the effects of cold than other surrounding tissue

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Exposure to cooling via energy extraction causes fat cell apoptosis – a natural, controlled cell death, which leads to the release of cytokines and other inflammatory mediators that gradually eliminate the affected cells.

Inflammatory cells gradually digest the affected fat cells in the months after the procedure, reducing the thickness of the fat layer.

Lipids from the fat cells are slowly released and transported by the lymphatic system to be processed and eliminated, much like that of fat from food.

Based on their research findings, the investigators concluded prolonged, controlled local tissue cooling can induce selective fat cell reduction and subsequent loss of subcutaneous fat, without damaging the overlying skin. This discovery, called selective Cryolipolysis led to the development of the patented technology behind the non-invasive CoolSculpting procedure.

Why the coolsculpting procedure is different?
The CoolSculpting procedure using Cryolipolysis is fundamentally different from other non- or minimally invasive modalities. Other methods of fat removal primarily involve necrotic cell death by damaging fat with heat, high-intensity focused ultrasound, or chemical injections. Each approach poses potential technical challenges, particularly with respect to targeting the right tissue depth and unintended damage to other structures close to or within the fat layer. Predictability of efficacy using these other techniques is also uncertain. In contrast, the CoolSculpting procedure using Cryolipolysis induces apoptosis only in fat cells to gently and gradually reduce the fat layer while preserving all other tissue.

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How non-invasive cryolipolysis works ?
Some stubborn fat are immune to diet and exercise

Freeze targeted fat with Coolsculpting procedure
CoolSculpting targets and cools fat cells to temperatures that trigger fat cell apoptosis

Post Coolsculpting procedure fat freeze
No damage to nerves or other tissues because lipids in fat crystallize at the warmer temperature than water in other cell types

Fat cells eliminated after Coolsculpting
Following treatment, fat cells enter an apoptotic death sequence and are gradually removed in the next few weeks and months by the immune system

Eliminated fat cells photo
Fat layer thickness significantly reduced

Lovehandles removed by Coolsculpting
Fat layer reduction in targeted area leads to an improvement in flank appearance

FREQUENTLY ASKED QUESTIONS
WHAT IS CRYOLIPOLYSIS ?

Cryolipolysis is the non-invasive cooling of adipose tissue to induce lipolysis (breaking down fat cells) without damage to other tissues. The result over two to four months is a noticeable, natural-looking reduction in fat.

HOW DOES IT WORK ?

Cryolipolysis is based on the principle that fat cells are more vulnerable to energy extraction (cooling) than surrounding tissues.(1) A non-invasive applicator is attached to the targeted procedure area to extract energy from the underlying fat tissue, while protecting the skin, nerves, muscles and other tissue. The cooled fat cells undergo apoptosis (controlled cell death) and are gradually eliminated, reducing the thickness of the fat layer.

WHAT HAPPENS TO FAT CELLS ?

During the procedure, exposure to cooling causes fat cell apoptosis, which leads to the release of cytokines and other inflammatory mediators. Inflammatory cells gradually digest the affected fat cells in the months after the procedure. Lipids from the fat cells are slowly released and transported by the lymphatic system to be processed, much like fat from food. Because the lipid clearance process is gradual there is no harmful change in blood lipids or liver function.

HOW COLD IS COLD ?

Lipids in fat cells crystallize at warmer temperatures than other water-containing cells. This is how Cryolipolysis targets only fat cells for destruction and spares other tissue such as skin, muscle, and nerves. The CoolSculpting system controls the rate of energy extraction or cooling during the procedure.

WHO DEVELOPED CRYOLIPOYSIS ?

Cryolipolysis research team proved that, under carefully controlled laboratory conditions, subcutaneous fat cells are naturally more vulnerable to the effects of cold than other surrounding tissues. Their initial evidence, published in Lasers in Surgery and Medicine in November 2008, concluded that prolonged, controlled local tissue cooling can induce selective fat cell reduction and subsequent loss of subcutaneous fat without damaging the overlying skin.(1) This discovery, called “selective cryolysis,” led to the development of the patented technology behind the non-invasive CoolSculpting procedure.

WHAT IS THE COOLSCULPTING PROCEDURE ?

The CoolSculpting procedure is a new non-invasive method clinically proven to reduce fat. CoolSculpting is clinically proven to reduce the fat layer(2),(3). Fat is uniquely susceptible to cold while sparing all other tissue. The mechanism of action is Cryolipolysis.

HOW IS THE COOLING DELIVERED TO THE FAT LAYER ?

Clients experiencing fat layer reduction show persistent results at least six months after the CoolSculpting treatment. Longer-term studies have not yet been completed. It is known that the exposure to cooling causes the fat cells to begin a process of natural removal, which gradually reduces the thickness of the fat layer. The fat cells in the treated area are gently eliminated through the body’s normal metabolism process, like fat from food. The elimination of fat cells as a result of the CoolSculpting procedure is expected to last about as long as fat cells removed by invasive procedures such as liposuction.

HOW DO THE RESULTS COMPARE WITH INVASIVE PROCEDURES SUCH AS LIPOSUCTION ?

The results of the CoolSculpting procedure are not as rapid or dramatic as invasive procedures such as liposuction. However, for patients who wish to avoid the pain, risk and recovery time associated with surgical procedures, the CoolSculpting procedure may be the preferred option.

WHAT ARE COMMON SIDE EFFECTS AFTER THE PROCEDURE ?

The CoolSculpting procedure is completely non-invasive, which allows immediate return to normal activities such as work or exercise. Redness may appear in the treated area, and may last from a few minutes to a few hours. Some localized bruising or swelling may occur, which clears within a few weeks. Many patients experience a temporary dulling of sensation in the treated area, lasting one to eight weeks.

WHICH PATIENT CAN BE BEST CANDIDATE ?

Ideal candidates for the CoolSculpting procedure are relatively fit, but have some modest-size fat bulges that are not easily reduced through diet and exercise. They are seeking spot reduction for specific areas of fat, but are not considering a surgical procedure. The CoolSculpting procedure is not intended for weight loss or obesity, and it is not a substitute for invasive methods such as liposuction.

HOW IS COOLSCULPTING PROCEDURE DIFFERENT FROM OTHER PROCEDURE ?

The controlled cooling of the CoolSculpting procedure targets and eliminates only fat cells. Other treatment modalities, such as lasers, radiofrequency and focused ultrasound, affect fat cells and may affect other adjacent tissue in a way that is not comparable to the CoolSculpting method of Cryolipolysis.

IS THE COOLSCULPTING PROCEDURE RECOMMENDED FOR CELLULITE ?

Well-controlled studies to determine whether the fat-reducing effects of the CoolSculpting procedure will result in the improved appearance of cellulite have not been completed. We does not recommend the CoolSculpting procedure using the current applicators for cellulite at present.

WHERE COOLSCULPTING PROCEDURE AVAILABLE?

The CoolSculpting procedure for non-invasive fat layer reduction is available worldwide now.